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Table 3 GO terms significantly over-represented among the transcripts differentially expressed between control and CO2 stressed oysters. This table includes GO (GO_BP = Biological process, GO_MF = Molecular function), COG (Clusters of Orthologous Groups) and eggNOG (evolutionary genealogy of genes: Non-supervised Orthologous Groups) terms that were found to be significantly over-represented among the transcripts differentially expressed in S. glomerata exposed to elevated levels of CO2 when compared to control oysters

From: Molecular analysis of the Sydney rock oyster (Saccostrea glomerata) CO2 stress response

Category Term Count p-value over-represented in
GO_BP Oxidation-reduction process 15 0.0013 control
Carbohydrate metabolic process 8 0.0019 control
Regulation of apoptotic process 5 0.0077 elevated CO2
GO_MF Oxidoreductase activity 7 0.0096 control
Copper ion binding 6 1.00E-04 control
O-glycosyl hydrolase activity 5 0.0024 control
Carbon-nitrogen hydrolase activity 3 0.0065 control
Peptidyl-dipeptidase activity 2 0.001 control
Cation binding 2 0.0017 control
Calcium ion binding 14 9.00E-04 elevated CO2
Alternative oxidase activity 2 2.00E-04 elevated CO2
Calcium-dependent phospholipid binding 2 0.0056 elevated CO2
COG Endonuclease IV plays a role in DNA repair 1 0.0084 control
Alkaline phosphatase 2 0.0044 elevated CO2
Homocysteine s-methyltransferase 1 0.0049 elevated CO2
eggNOG Glutathione S-transferase 2 3.00E-04 control
Activating signal cointegrator 1 complex subunit 2 5.00E-04 control
Leucine-rich repeat extensin-like protein 2 7.00E-04 control
Niemann-Pick disease 2 7.00E-04 control
Angiotensin I converting enzyme peptidyl-dipeptidase A 2 0.001 control
RNA binding motif protein 2 0.0019 control
WD repeat domain 83 opposite strand 1 0.0044 control
Chromosome 5 open reading frame 63 1 0.0053 control
Kiaa1524 1 0.0056 control
Collectin sub-family member 12 1 0.0085 control
Solute carrier family 17 3 0.0013 elevated CO2
Alternative oxidase 2 1.00E-04 elevated CO2
K06254 agrin 2 2.00E-04 elevated CO2
Hydrolase family 2 0.0015 elevated CO2
Annexin A7 2 0.0019 elevated CO2
Ribosomal protein l21 1 0.0092 elevated CO2
Family with sequence similarity 210 1 0.0092 elevated CO2
Follistatin 1 0.0096 elevated CO2