Table 3 GO terms significantly over-represented among the transcripts differentially expressed between control and CO₂ stressed oysters. This table includes GO (GO_BP = Biological process, GO_MF = Molecular function), COG (Clusters of Orthologous Groups) and eggNOG (evolutionary genealogy of genes: Non-supervised Orthologous Groups) terms that were found to be significantly over-represented among the transcripts differentially expressed in S. glomerata exposed to elevated levels of CO₂ when compared to control oysters

GO_BP

Oxidation-reduction process

15

control

Carbohydrate metabolic process

8

control

Regulation of apoptotic process

5

elevated CO₂

GO_MF

Oxidoreductase activity

7

control

Copper ion binding

6

control

O-glycosyl hydrolase activity

5

control

Carbon-nitrogen hydrolase activity

3

control

Peptidyl-dipeptidase activity

2

control

Cation binding

2

control

Calcium ion binding

14

elevated CO₂

Alternative oxidase activity

2

elevated CO₂

Calcium-dependent phospholipid binding

2

elevated CO₂

COG

Endonuclease IV plays a role in DNA repair

1

control

Alkaline phosphatase

2

elevated CO₂

Homocysteine s-methyltransferase

1

elevated CO₂

eggNOG

Glutathione S-transferase

2

control

Activating signal cointegrator 1 complex subunit

2

control

Leucine-rich repeat extensin-like protein

2

control

Niemann-Pick disease

2

control

Angiotensin I converting enzyme peptidyl-dipeptidase A

2

control

RNA binding motif protein

2

control

WD repeat domain 83 opposite strand

1

control

Chromosome 5 open reading frame 63

1

control

Kiaa1524

1

control

Collectin sub-family member 12

1

control

Solute carrier family 17

3

elevated CO₂

Alternative oxidase

2

elevated CO₂

K06254 agrin

2

elevated CO₂

Hydrolase family

2

elevated CO₂

Annexin A7

2

elevated CO₂

Ribosomal protein l21

1

elevated CO₂

Family with sequence similarity 210

1

elevated CO₂

Follistatin

1

elevated CO₂